Effect of parenteral iron treatment on platelet counts in women who do not have concomitant diseases

Alanli R., Kucukay M. B.

Iraqi Journal of Hematology, cilt.11, sa.1, ss.56-59, 2022 (ESCI)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 11 Sayı: 1
  • Basım Tarihi: 2022
  • Doi Numarası: 10.4103/ijh.ijh_7_22
  • Dergi Adı: Iraqi Journal of Hematology
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI)
  • Sayfa Sayıları: ss.56-59
  • Lokman Hekim Üniversitesi Adresli: Evet

Özet

Abstract:

BACKGROUND: Iron replacement may change platelet counts. Parenteral iron treatment has

different effects on platelets count in some diseases. the aim of this study was to inspect the effect

of parenteral ferric carboxymaltose treatment on platelet counts and other hemogram parameters

in females who have no other diseases, but iron deficiency.

MATERIALS AND METHODS: This study was conducted in a university hospital located in Ankara,

Turkey, between January 2020 and October 2021. A total of 239 female participants who were

diagnosed with iron deficiency and who were given parenteral ferric carboxymaltose treatment were

included in the study. Participants were divided into two groups according to the existence of anemia.

Hemogram parameters, ferritin, and C‑reactive protein levels before and 3 months after parenteral

ferric carboxymaltose treatment were compared between these two groups.

RESULTS: Hemoglobin and ferritin levels were increased (P < 0.001) and platelet counts (P < 0.001)

and mean platelet volumes (MPVs) (P = 0.015) were decreased after parenteral ferric carboxymaltose

treatment. In both groups, hemoglobin levels were increased and platelet counts were decreased,

but in the group with patients having anemia, changes in hemoglobin levels and platelet counts were

more prominent after treatment (P < 0.001). When compared to initiation of treatment, there was a

significant negative correlation after treatment regarding changes in hemoglobin levels and platelet

counts (r = ‒0.369, P < 0.001).

CONCLUSION: Parenteral ferric carboxymaltose treatment resulted in a decrease in platelet counts

and MPV values compared to initiation of treatment. Parenteral ferric carboxymaltose treatment

resulted in decreases in platelet counts and independent from correction of anemia.

Keywords:

Ferric carboxymaltose, iron deficiency, platelet count