Simultaneous determination of acetaminophen, acetylsalicylic acid and ascorbic acid in tablet form using HPLC

Akay C., Gümüsel B., Degim T., Tartilmis S., Cevheroglu S.

Drug Metabolism and Drug Interactions, vol.15, no.2-3, pp.197-205, 1999 (Scopus) identifier identifier

  • Publication Type: Article / Abstract
  • Volume: 15 Issue: 2-3
  • Publication Date: 1999
  • Doi Number: 10.1515/dmdi.1999.15.2-3.197
  • Journal Name: Drug Metabolism and Drug Interactions
  • Journal Indexes: Scopus, PASCAL, Chemical Abstracts Core
  • Page Numbers: pp.197-205
  • Keywords: Acetaminophen, Acetylsalicylic acid, Ascorbic acid, HPLC, Simultaneous measurement
  • Lokman Hekim University Affiliated: No


The purpose of the present study was to develop a simple and accurate HPLC method to measure the amount of each agent in a multidrug pharmaceutical formulation. Three drugs, acetaminophen, acetylsalicylic acid and ascorbic acid, were analyzed simultaneously. A commercial pharmaceutical effervescent tablet was examined and the amount of each of these agents successfully determined. The present method appears to be more convenient than the current procedures described in American and British Pharmacopoeias in which each drug is assayed separately.