Akademik Veri Yönetim Sistemi
S.T.P. Pharma Sciences, cilt.8, sa.3, ss.203-208, 1998 (SCI-Expanded)
Three new methods were used for the quantitative analysis of a tablet formulation containing pseudoephedrine hydrochloride and triprolidine hydrochloride: first derivative spectrophotometry, ratio spectra derivative spectrophotometry and Vierordt's method. In the first method, dA/dλ values were measured at 264.0 nm for pseudoephedrine hydrochloride and at 291.8 nm for triprolidine hydrochloride in the first derivative, and the calibration graphs were linear from 200 to 1200 μg/ml for pseudoephedrine hydrochloride and 10 to 50 μg/ml for triprolidine hydrochloride. In the second method, the calibration graphs for 120 to 1200 μg/ml pseudoephedrine hydrochloride and for 5 to 50 μg/ml triprolidine hydrochloride were obtained by measuring the analytical signals at 266.3 nm for pseudoephedrine hydrochloride and at 275.4 nm for triprolidine hydrochloride. In the third method, absorptivity A11 (%1, 1 cm) values were calculated by using the absorbances measured at 256.8 nm and 278.1 nm in the zero-order spectra for each of active compounds in the binary mixture. The quantities of both compounds were calculated by means of equations with two unknowns using the A11 (%1, 1 cm) values. The methods were applied to determine both compounds in a pharmaceutical product.