Therapeutic Potential of alpha- and beta-Pinene: A Miracle Gift of Nature

Creative Commons License

Salehi B., Upadhyay S., ERDOĞAN ORHAN İ., Jugran A. K., Jayaweera S. L. D., Dias D. A., ...More

BIOMOLECULES, vol.9, no.11, 2019 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 9 Issue: 11
  • Publication Date: 2019
  • Doi Number: 10.3390/biom9110738
  • Journal Name: BIOMOLECULES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: alpha-pinene, beta-pinene, pharmacological activities, cytotoxicity, bioavailability, clinical studies, ESSENTIAL OIL COMPONENTS, NF-KAPPA-B, SALVIA-LAVANDULAEFOLIA, CHEMICAL-COMPOSITION, ANTIINFLAMMATORY ACTIVITY, ANTIMICROBIAL EVALUATION, PHARMACOLOGICAL-ACTIVITY, ANTIOXIDANT ACTIVITIES, BIOLOGICAL-ACTIVITIES, MAJOR CONSTITUENT
  • Lokman Hekim University Affiliated: No

Abstract

alpha- and beta-pinene are well-known representatives of the monoterpenes group, and are found in many plants' essential oils. A wide range of pharmacological activities have been reported, including antibiotic resistance modulation, anticoagulant, antitumor, antimicrobial, antimalarial, antioxidant, anti-inflammatory, anti-Leishmania, and analgesic effects. This article aims to summarize the most prominent effects of alpha- and beta-pinene, namely their cytogenetic, gastroprotective, anxiolytic, cytoprotective, anticonvulsant, and neuroprotective effects, as well as their effects against H2O2-stimulated oxidative stress, pancreatitis, stress-stimulated hyperthermia, and pulpal pain. Finally, we will also discuss the bioavailability, administration, as well as their biological activity and clinical applications.