Invasive pulmonary aspergillosis after liver transplantation: Rapid and complete response to combined and sequential antifungal therapy

Can M. F., Yagci G., Gorenek L., Tozkoparan E., ÖZERHAN İ. H., Cetiner S.

Surgical Infections, vol.9, no.1, pp.99-104, 2008 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 9 Issue: 1
  • Publication Date: 2008
  • Doi Number: 10.1089/sur.2006.094
  • Journal Name: Surgical Infections
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.99-104
  • Lokman Hekim University Affiliated: No


Background: Invasive pulmonary aspergillosis is a rare, but severe and potentially fatal, complication after liver transplantation. There is no therapeutic regimen accepted worldwide for both initial and continuation therapy; nevertheless, several options have been proposed. Methods: Case report and review of the pertinent English-language literature. Results: In a patient with pulmonary aspergillosis after a liver transplant, combined and sequential therapy with caspofungin and voriconazole with termination of the immunosuppressive regimen and careful management were helpful to control the infection rapidly, possibly because of a positive drug interaction. Conclusion: In cases of invasive aspergillosis that are refractory to monotherapy, this regimen may be used in an attempt to overcome the infection. © 2008 Mary Ann Liebert, Inc.