Akademik Veri Yönetim Sistemi
STUDIA UNIVERSITATIS BABES-BOLYAI CHEMIA, cilt.4, ss.115-127, 2024 (SCI-Expanded)
Cholinesterase inhibitors are valuable compounds that can be
used in many different therapeutic applications, including Alzheimer’s disease.
Carbonic anhydrase (CA) inhibitors constitute a pharmacological intervention
employed for the management and alleviation of various medical conditions,
including glaucoma, idiopathic intracranial hypertension. Turkey has a large
and diverse flora, home to thousands of plant species. Hundreds of compounds
of medicinal importance have been identified from the many plants in this
flora. In this study, the inhibitory properties of seven different plant extracts on
CA I and II, acetylcholinesterase (AChE) and butyrylcholinesterase (BChE)
enzymes were investigated. The tested extracts showed AChE inhibitory
activity with values ranging from 1.26 to 4.20 μg/mL, BChE inhibitory activity
with values ranging from 1.32 to 4.24 μg/mL, CA I inhibitory activity with values
ranging from 0.74 to 1.82 μg/mL and CA II inhibitory activity with values
ranging from 0.033 to 0.067 μg/mL. The extract of Zosima absinthifolia showed
a very active inhibition profile against both AChE and BChE (IC50 1.26 ± 0.01
μg/mL for AChE and 1.32 ± 0.02 μg/mL for BChE). The results indicate that
these extracts are potent cholinesterases inhibitors and specifically Zosima
absinthifolia extract could be evaluated for further studies.