An investigation of oxidative stress and thiol/disulphide homeostasis in Graves’ disease

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Agan V., Celik H., Eren M. A., Agan F. Z., EREL Ö., NEŞELİOĞLU S., ...More

Medicina (Lithuania), vol.55, no.6, 2019 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Review
  • Volume: 55 Issue: 6
  • Publication Date: 2019
  • Doi Number: 10.3390/medicina55060275
  • Journal Name: Medicina (Lithuania)
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: Graves’ disease, Oxidative stress, Thiol/disulphide homeostasis
  • Lokman Hekim University Affiliated: No


Background and objectives: The aim of this study was to research oxidative stress and thiol/disulphide homeostasis in Graves’ patients. Materials and Methods: The study included 33 Graves’ patients (research group) and 35 healthy subjects (control group). Serum oxidative stress and thiol/disulphide homeostasis (a new and automated spectrophotometric method developed by Erel and Neselioglu) parameters were studied and compared between the groups. Results: The native and total thiol levels and the native thiol/total thiol ratio were lower in patients with Graves’ disease compared to the control group (p < 0.001, p < 0.001, and p = 0.006, respectively). TOS (total antioxidant status), PC (protein carbonyl), OSI (Oxidative stress index), and disulphide/native thiol and disulphide/total thiol ratios were determined to be higher in the Graves’ disease group than in the control group (p < 0.001, p = 0.001, p = 0.001, p = 0.004, and p = 0.006, respectively). In the Graves’ disease group, the free triiodothyronine (FT3) and free thyroxine (FT4) levels were significantly positively correlated with impaired thiol/disulphide homeostasis and oxidative stress parameters (p < 0.05). Conclusion: The results of the current study demonstrated that oxidative stress and thiol/disulphide homeostasis increased towards disulphide formation due to thiol oxidation in Graves’ disease. In addition, a positive correlation of FT3 and FT4 was observed with oxidative stress parameters and impaired thiol/disulphide homeostasis.