Relationship between asthma and IL-17 gene polymorphism in a Turkish population

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Yuce G. D., Erdogan T., Bozkurt B., Toprak U., GÜLEÇ CEYLAN G.

IRISH JOURNAL OF MEDICAL SCIENCE, vol.192, no.1, pp.269-275, 2023 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 192 Issue: 1
  • Publication Date: 2023
  • Doi Number: 10.1007/s11845-022-02956-5
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Biotechnology Research Abstracts, EMBASE, MEDLINE
  • Page Numbers: pp.269-275
  • Keywords: Asthma, IL-17, Polymorphism, rs763780, rs2275913, rs8193036, INTERLEUKIN 17A, ASSOCIATION, RISK, SUSCEPTIBILITY, DISEASE, IL17F, LUNG
  • Lokman Hekim University Affiliated: Yes


Background Asthma is a prevalent chronic obstructive disease of the airways. Aims The aim of our study was to investigate the relationship between asthma and IL-17F gene 74488 T > C, IL-17A gene -197G > A, and IL17A gene -737C > T polymorphisms in Turkish population. Methods In our study, peripheral blood samples collected from a total of 127 subjects, with 65 in the patient group and 62 in the control group, were analyzed for IL-17F gene 74488 T > C, IL-17A gene -197G > A, and IL17A gene -737C > T polymorphisms using next-generation sequencing. Results There was no statistically significant relationship between IL-17A gene -197G > A and IL-17A gene -737C > T polymorphisms and the risk of developing asthma. It was found that the risk of developing asthma was 2.9-fold higher in individuals with a C allele in the IL-17F gene 7488 T > C polymorphic site than the individuals with a T allele. It was shown that ATT and GCT haplotype carriers had a greater disease risk compared with the GTT haplotype carriers. Conclusions In conclusion, IL-17F gene 7488 T > C polymorphism was found to be associated with asthma in the Turkish population. The IL-17 gene should be further investigated as a potential candidate gene in predicting asthma susceptibility and in the treatment of asthma.