Pleural effusion due to imatinib: Case report İmatinib'e baģli plevral efüzyon

Akpinar S., Uçar N., Akpinar E., Dursun A. B., Örsel O., Şipit T.

Turkiye Klinikleri Journal of Medical Sciences, cilt.29, sa.1, ss.258-262, 2009 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 29 Sayı: 1
  • Basım Tarihi: 2009
  • Dergi Adı: Turkiye Klinikleri Journal of Medical Sciences
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.258-262
  • Anahtar Kelimeler: Imatinib, Leukemia, myeloid, chronic-phase, Pleural effusion
  • Lokman Hekim Üniversitesi Adresli: Hayır

Özet

One of the most important side effects of tyrosine kinase inhibitors, which are the first line treatment options in chronic myleoid leukemia (CML), is lung abnormalities among which pleural effusion is the most important. A 25-year-old female patient with CML for 10 months who has been treated with imatinib was admitted due to shortness of breath and back pain. Warfarin was started three months ago with the diagnosis of pulmonary thromboembolism. Chest X-ray revealed bilateral pleural effusion. Thorax computerized tomography angiography performed in order to exclude recurrent pulmonary thromboembolism revealed thrombosis. Thorasynthesis yielded an exudative pleural fluid with a predominance of lymphocytes. The patient improved radiologically and clinically improvement after stopping imatinib, while the etiology of pleurisy was being investigated. This interesting case was discussed reviewing the literature. Copyright © 2009 by Türkiye Klinikleri.