Effects of phenylpropanoid and iridoid glycosides on free radical-induced impairment of endothelium-dependent relaxation in rat aortic rings

Ismailoglu U., Saracoglu I., Harput U., Sahin-Erdemli I.

JOURNAL OF ETHNOPHARMACOLOGY, cilt.79, sa.2, ss.193-197, 2002 (SCI-Expanded) identifier identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 79 Sayı: 2
  • Basım Tarihi: 2002
  • Doi Numarası: 10.1016/s0378-8741(01)00377-4
  • Dergi Adı: JOURNAL OF ETHNOPHARMACOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.193-197
  • Anahtar Kelimeler: phenylpropanoid glycosides, iridoids, Phlomis pungens var. pungens, rat aorta, endothelium dependent relaxation, electrolysis, free radical scavenger activity, PROTECTION
  • Lokman Hekim Üniversitesi Adresli: Hayır

Özet

The protective effect of phenylpropanoid glycosides, forsythoside B and alyssonoside, and the iridoid glycoside lamiide, isolated from the aerial parts of Phlomis pungens var. pungens, against free radical-induced impairment of endothelium-dependent relaxation in isolated rat aorta was investigated. Aortic rings were exposed to free radicals by the electrolysis of the physiological bathing solution. Free radical-induced inhibition of the endothelium-dependent relaxation in response to acetylcholine was countered by incubation of the aortic rings before electrolysis with the aqueous extract (100 mug/ml), phenylpropanoid fraction (100 mug/ml) and iridoid fraction (150 mug/ml) of P. pungens var. pungens. Major components of the phenylpropanoid fraction forsythoside B and alyssonoside also prevented the inhibition of the acetylcholine response, at 10(-4) M concentration. However, the major component of iridoid fraction lamiide was found ineffective at the same concentration. The protective activity of phenylpropanoid glycosides against the free radical-induced impairment of endothelium-dependent relaxation may be related to their free radical scavenging property. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.