Akademik Veri Yönetim Sistemi
2nd International Multidisciplinary Cancer Research Congress, Giresun, Türkiye, 21 - 24 Temmuz 2022, cilt.9786250008867, ss.92
Introduction and Aim: Breast cancer is the most common type of cancer in women and the
most common cause of cancer-related death after lung cancer. While approximately 70-80% of
non-metastatic cancers can be treated, breast cancer with distant metastases is considered
incurable with current treatments. Although the common treatment methods in the treatment of
breast cancer are chemotherapy, radiotherapy and surgery, the search for alternative treatments
continues. The leading alternative treatments are medicinal plants which actually inspire the
production of many cancer drugs. In this study, the proliferative and metastatic effects of
Carthamus tinctorius L.(safflower), known for its many therapeutic properties, on metastatic
breast cancer were investigated.
Materials and Methods: Safflower leaves were extracted in water, alcohol and oil and the
extracts were applied to 0.04 g/ml metastatic breast cancer cells. To evaluate the mechanisms
of different extracts of the safflower plant on metastatic breast cancer cells; MTT assay, wound
healing assay and gene expression analysis were performed.
Results: It is found that, there is no difference in proliferation between the cells to which the
safflower extracts were applied and the control cells. However, all safflower extracts, especially
the oil extract, significantly reduced the metastatic potential (migration and MMP9/TIMP1
gene expression ratio) of breast cancer cells.
Conclusion: It is concluded that safflower contents are potent chemicals which inhibit the
cellular mechanisms underlying the spreading of cancer cells and further analysis may lead to
new initiatives in drug design research