Dicle Medical Journal , cilt.40, sa.1, ss.105-108, 2013 (Hakemli Dergi)
ABSTRACT
Prostaglandin E1 infusion is widely used to maintain patency of ductus arteriosus in newborns with duct-dependent congenital heart disease until surgery. Prostaglandin
E1 is a lifesaving drug, but it has many side effects including fever, apnea, bradycardia, hypotension, convulsion,
edema, and cortical hyperostosis. The gastrointestinal
tract has not been recognized as a major site of serious
adverse effects of prostaglandin E1 infusion, although
diarrhea is a well-recognized side effect that usually responds to dose reduction. In this report, we present a
case of intestinal intussusception presumably induced by
prostaglandin therapy in a newborn with duct-dependent
congenital heart disease.
Key words: Prostaglandin E1, newborn, gastrointestinal