Hepatoprotective and antioxidant effects of lycopene in acute cholestasis

Creative Commons License

Tokaç M., Aydin S., Taner G., ÖZKARDEŞ A. B., Yavuz Taşlipinar M., Doğan M., ...Daha Fazla

Turkish Journal of Medical Sciences, cilt.45, sa.4, ss.857-864, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 45 Sayı: 4
  • Basım Tarihi: 2015
  • Doi Numarası: 10.3906/sag-1404-57
  • Dergi Adı: Turkish Journal of Medical Sciences
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.857-864
  • Anahtar Kelimeler: Lycopene, cholestasis, DNA damage, oxidative stress, peripheral lymphocytes, liver, RENAL OXIDATIVE STRESS, BILE-DUCT LIGATION, DNA-DAMAGE, OBSTRUCTIVE-JAUNDICE, HEPATIC-INJURY, LIVER, RATS, LYMPHOCYTES, MECHANISMS, MELATONIN
  • Lokman Hekim Üniversitesi Adresli: Hayır

Özet

© TÜBİTAK.Background/aim: Lycopene, which is suggested to be a potent antioxidant, may play a protective role in diseases related to oxidative stress. In order to understand the effects of lycopene in the pathogenesis of cholestasis, we investigated the effects of lycopene on oxidative stress parameters and DNA damage induced by experimental biliary obstruction in the liver tissues and the lymphocytes of Wistar albino rats. Materials and methods: The animals were randomized into 3 groups. The sham group was subjected to a sham operation, the BDL group was subjected to bile duct ligation (BDL), and the BDL+L group was subjected to BDL and treated with 10 mg/kg body weight of lycopene. After 7 days of treatment, the liver functions, oxidative stress parameters, and DNA damage were evaluated. Results: The lycopene treatment significantly ameliorated the liver function parameters in BDL rats. It significantly reduced malondialdehyde and nitric oxide levels and enhanced reduced glutathione levels and catalase, superoxide dismutase, and glutathione S transferase activities in the BDL rats. The lycopene treatment also decreased DNA damage as assessed by comet assay in the lymphocytes and hepatocytes of the BDL rats. Conclusion: These results suggest that lycopene might have protective effects on acute cholestasis.