Akademik Veri Yönetim Sistemi
Anestezi Dergisi, cilt.19, sa.3, ss.162-176, 2011 (Scopus)
Objective: The clinical condition which is a result of long-term infusion of propofol defined as Propofol Infusion Sendrome (PRIS) is a rare syndrome which can lead to lactic acidosis, lipemic plasma, pancreatit and cardiac failure and is often fatal. In our study, we aimed to evaluate metabolic and biochemical effects of infusion of propofol for long term sedation of rabbits undergoing mechanical ventilation. Methods: 2500-3500 gr weight, 3-4 months, male, white 12 New Zealand rabbits were used in the study. After the rabbits were premedicated with xylazine and atropine, after induction with ketamine, rabbits were opened tracheostomy and were connected the ventilator. Group 1 (PI + Saline, n.6): In this group 2% injectable lipid solution of propofol infused to animals at a rate of 20 mg-1 kg-1 hr. Group 2 (Sevoflurane + Saline, n:6): In this group inhalation anesthesia with 1.5% sevoflurane in 100% oxygen of 4 L-1 min was started. The sedation levels of all animals were evaluated for every 30 minutes; sedation level (BIS level is between 40-60), the propofol infusion rate and sevoflurane percentage in 100% O2 were changed according to clinical or vital signs. All their vital signs (heart rate, invazive arterial pressure, SpO2, body temperature, BIS values and urine output) were observed for every 15 minutes. Arterial blood gases analysis were obtained every 2 hours and other biochemical parameters were obtained every 12 hours. Anesthesia methods used in the animals in all groups were continued until the animals died or during 24 hours. Results: In this study we found that; when compared to two groups; in the propofol group; levels of cholesterol, trigliserid and VLDL were higher than in the sevoflurane group at 12th and 24th hours. Levels of CK-MB at 24th hours, myoglobuline and amylase levels at 12th hours in the propofol group were higher than in the sevoflurane group. We observed that rabbits who were in the propofol group had decreased sodium levels and increased potassium and phosphorus levels statistically. Conclusion: Although this model which was created with high doses propofol in healty animals who undergoing mechanical ventilation, is not a reflection of the intensive care patients who had mechanical ventilation for treatment of critical illness, it can be used to become known biochemical and metabolic mechanism of infusion of propofol. So that the mechanism can be used for investigate the treatment models for occur ability of like PRIS syndrome treatment.