Adrenotensin: An ADM gene product with the opposite effects of ADM


Gumusel B., Chang J., Hyman A., Lippton H.

Life Sciences, vol.57, no.8, 1995 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 57 Issue: 8
  • Publication Date: 1995
  • Doi Number: 10.1016/0024-3205(95)02012-8
  • Journal Name: Life Sciences
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: ADRENOMEDULLIN GENE, ADRENOTENSIN, VASOCONSTRICTION, HYPOTENSIVE PEPTIDE, ADRENOMEDULLIN
  • Lokman Hekim University Affiliated: No

Abstract

The purpose of the present study was to investigate the effects of putative products of the ADM gene, other than ADM including, prodepin, proADM45-92 and proADM153-185 on cat pulmonary arterial (PA) rings with or without precontraction with U46619. Addition of proADM153-185 (3×10-10-10-6M) increased tension in a concentration-dependent manner in cat PA rings without precontraction. When vessels were precontracted with U46619, ADM(3×10-10-10-6M) produced a concentration-dependent vasorelaxant response, whereas proADMus-iss produced a weak concentration-dependent contractile response. Prodepin and proADM45-92 up to 10-6M had no activity on PA rings. Since proADM1531̄85, similar to ADM, would be expected to be released in free form following endopeptidase-induced cleavage, the present data suggest proADM undergoes proteolytic processing to release peptides with divergent vascular effects.Thus, the present data also suggest that proADM153-185 may represent a novel product of the ADM gene and term this putative new substance "adrenotensin". © 1995.