Synthesis and potent antifungal activity against Candida species of some novel 1H-benzimidazoles

GÖKER A. H., ALP M., ALAGÖZ Z., YILDIZ S.

Journal of Heterocyclic Chemistry, cilt.46, sa.5, ss.936-948, 2009 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 46 Sayı: 5
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1002/jhet.179
  • Dergi Adı: Journal of Heterocyclic Chemistry
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.936-948
  • Lokman Hekim Üniversitesi Adresli: Hayır

Özet

(Chemical Equation Presented) A series of 47 novel N1-alkylated- 2-aryl-5(6)-substituted-1H-benzimidazoles and their three novel indole analogues were synthesized and evaluated for in vitro antifungal activities against Candida species by the tube dilution method. The results showed that compounds 79 and 80, having pyridine at the position C-2, of benzimidazoles exhibited the greatest activity with MIC values of 6.25-3.12 μg/mL. Indole analogues 108-110 have no inhibitory activity. © 2009 HeteroCorporation.