Administration of MINE protocol in untreated patients with intermediate and high grade non-Hodgkin's lymphoma
Haematologia, vol.28, no.4, pp.207-213, 1997 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 28 Issue: 4
- Publication Date: 1997
- Journal Name: Haematologia
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.207-213
- Keywords: Combination chemotherapy, Ifosfamide, Mitoxantrone, Non-Hodgkin's lymphoma
- Lokman Hekim University Affiliated: Yes
Abstract
In recent years, more effective and less toxic treatment protocols have been developed to increase the cure rates in intermediate and high grade non- Hodgkin's lymphoma (NHL). This study was undertaken to investigate the efficacy and toxicity of MINE (ifosfamide, mesna, mitoxantrone and etoposide) combination chemotherapy in patients with intermediate and high grade NHL. Twenty-one patients (16 male, 5 female; age between 26 and 70 years) with NHL were included in the study. An overall response rate of 73% and complete response rate of 56% were achieved and survival rate for responding patients was 80% at the 48th month. Side effects including mild myelosuppression, nausea/vomiting and alopecia were observed. MINE combination seems to be effective and well tolerated without significant toxicity as a first-line therapy in patients with intermediate or high grade NHL.