Enzyme Inhibitory Activities and RP-HPLC Analysis of Geranium andErodium Species

Özüpek B., Abacı Kaplan N., Gök H. N., Kahraman A., Deliorman Orhan D., Şenol Deniz F. S., ...Daha Fazla

CHEMISTRY AND BIODIVERSITY, cilt.2025, sa.22, ss.1-12, 2025 (SCI-Expanded)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 2025 Sayı: 22
  • Basım Tarihi: 2025
  • Doi Numarası: 10.1002/cbdv.202402065
  • Dergi Adı: CHEMISTRY AND BIODIVERSITY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Agricultural & Environmental Science Database, Aquatic Science & Fisheries Abstracts (ASFA), CAB Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.1-12
  • Lokman Hekim Üniversitesi Adresli: Evet

Özet

The genera Geranium and Erodium (Geraniaceae) have been

documented to possess diverse ethnopharmacological uses,

including diabetes mellitus. Relevant to their ethnopharmaco-

logical use, the current study aimed to evaluate the α-

glucosidase,α-amylase,acetylcholinesterase(AChE),andbutyr-

ylcholinesterase (BChE) enzyme inhibitory activity of ethanol

extracts from 46 samples belonging to thirty-one species of

Geranium (20) and Erodium (11) collected throughout Türkiye.

Themajorityoftheextractsdisplayedamarkedα-glucosidase

andα-amylaseinhibitoryactivity.Besides,23extractsoutof46

exhibited a concentration-dependent inhibitory effect over

50%towardsAChE.ThehighestAChEinhibitionwasfoundin

G. subcaulescens collected from Konya with an IC50 value of

4.73�2.96μg/mL.E.somanum,E.leucanthum,andE.sipthorpia-

numexhibitedthemostpotentα-glucosidaseinhibitoryactivity,

while E. birandianum and E. pelargoniiflorum were the most

active extracts against AChE and BChE, respectively. Three

extracts that had inhibitory activity over 50% against four of

theenzymeswereselectedandproceededtoRP-HPLCanalysis.

Geraniinandellagicacidwereidentifiedasmajorcompounds

in the active extracts. Most species screened in the current

studywereexaminedforthefirsttimeagainstα-glucosidase,α-

amylase,AChE,andBChE.