Enzyme Inhibitory Activities and RP-HPLC Analysis of Geranium andErodium Species

Özüpek B., Abacı Kaplan N., Gök H. N., Kahraman A., Deliorman Orhan D., Şenol Deniz F. S., ...More

CHEMISTRY AND BIODIVERSITY, vol.2025, no.22, pp.1-12, 2025 (SCI-Expanded, Scopus)

  • Publication Type: Article / Article
  • Volume: 2025 Issue: 22
  • Publication Date: 2025
  • Doi Number: 10.1002/cbdv.202402065
  • Journal Name: CHEMISTRY AND BIODIVERSITY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Agricultural & Environmental Science Database, Aquatic Science & Fisheries Abstracts (ASFA), CAB Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.1-12
  • Lokman Hekim University Affiliated: Yes

Abstract

The genera Geranium and Erodium (Geraniaceae) have been

documented to possess diverse ethnopharmacological uses,

including diabetes mellitus. Relevant to their ethnopharmaco-

logical use, the current study aimed to evaluate the α-

glucosidase,α-amylase,acetylcholinesterase(AChE),andbutyr-

ylcholinesterase (BChE) enzyme inhibitory activity of ethanol

extracts from 46 samples belonging to thirty-one species of

Geranium (20) and Erodium (11) collected throughout Türkiye.

Themajorityoftheextractsdisplayedamarkedα-glucosidase

andα-amylaseinhibitoryactivity.Besides,23extractsoutof46

exhibited a concentration-dependent inhibitory effect over

50%towardsAChE.ThehighestAChEinhibitionwasfoundin

G. subcaulescens collected from Konya with an IC50 value of

4.73�2.96μg/mL.E.somanum,E.leucanthum,andE.sipthorpia-

numexhibitedthemostpotentα-glucosidaseinhibitoryactivity,

while E. birandianum and E. pelargoniiflorum were the most

active extracts against AChE and BChE, respectively. Three

extracts that had inhibitory activity over 50% against four of

theenzymeswereselectedandproceededtoRP-HPLCanalysis.

Geraniinandellagicacidwereidentifiedasmajorcompounds

in the active extracts. Most species screened in the current

studywereexaminedforthefirsttimeagainstα-glucosidase,α-

amylase,AChE,andBChE.