Spectrophotometric simultaneous analysis of analgin - Adamon mixture in injection preparations
Analytical Letters, vol.29, no.5, pp.763-773, 1996 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 29 Issue: 5
- Publication Date: 1996
- Doi Number: 10.1080/00032719608001782
- Journal Name: Analytical Letters
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.763-773
- Keywords: Adamon, Analgin, Pharmaceutical preparation, Spectrophotometry
- Lokman Hekim University Affiliated: No
Abstract
A new method is described for analyzing a binary mixture of analgin and adamon using extractive and derivative spectrophotometry. In the method, analgin and adamon both were extracted into chloroform as an ion-pair with thymol blue from their aqueous solution buffered to pH 3.6. Determination of these drugs was performed by reading the dA/dλ values at 600.0 nm and 310 5 nm in the first derivative spectra of the chloroform layer. Relative standard deviations of the method are 0.10 % for analgin and 0 81 % for adamon. The method was successfully applied to an injection solution containing these two active ingredients.