Role of Tumour Microenvironment in Metastatic Breast Cancer

Kaçaroğlu D., Gürbüz N.

Nano Theragnostics in Breast Cancer : Advances, Challenges, and Future Prospects, Belagodu Sridhar Sathvik,Husain Warsi Musarrat,Malviya Rishabha, Editör, Springer, Singapore, ss.1-34, 2025

  • Yayın Türü: Kitapta Bölüm / Mesleki Kitap
  • Basım Tarihi: 2025
  • Yayınevi: Springer
  • Basıldığı Şehir: Singapore
  • Sayfa Sayıları: ss.1-34
  • Editörler: Belagodu Sridhar Sathvik,Husain Warsi Musarrat,Malviya Rishabha, Editör
  • Lokman Hekim Üniversitesi Adresli: Evet

Özet

Advanced breast cancer is marked by a high metastatic profile and poor long-term survival rates. It is generally more difficult to treat and has a worse prognosis. Metastasis to bone, liver, lung, lung, brain and lymphatic system is seen in breast cancer. The breast cancer microenvironment plays an important role affecting tumour growth, spread and response to treatment. The breast cancer microenvironment refers to the cellular, molecular, and vascular structures surrounding the tumor. In other words, tumor cells are not composed solely of cancer cells; there are also normal cells, fibroblasts , immune cells, lymphatic vessels, blood vessels extracellular matrix (ECM), and other component parts around them. All of these structures are referred to as the tumor microenvironment. Because of the disruption of ECM morphology, the development of an immunosuppressive tumor microenvironment facilitates proliferation and metastasis. The presence of this microenvironment decreases the success rate of therapeutic methods such as hormone therapy, immunotherapy, chemotherapy, and anti-angiogenic targeted therapies. In this section, the components of the breast tumor microenvironment; cancer cells, endothelial cells, immune cells, cancer-associated fibroblasts, pericytes, and ECM will be discussed in detail. The tumor microenvironment is a complicated environment that influences tumor cell proliferation, cellular metabolism, vascularization, drug response, immune cell response and metastasis pathways. To clarify this and intervene in the microenvironment, it is essential to clarify the role of microenvironmental components in breast cancer. This book chapter reviews microenvironmental elements and briefly presents therapeutic approaches targeting the immunomicroenvironment based on in preclinic and clinical phase studies.