Selective in vitro and in silico cholinesterase inhibitory activity of isoflavones and stilbenes from Belamcandae chinensis rhizoma

Slusarczyk S., ŞENOL DENİZ F. S., Wozniak D., Pecio L., Perez-Sanchez H., Ceron-Carrasco J. P., ...More

PHYTOCHEMISTRY LETTERS, vol.30, pp.261-272, 2019 (SCI-Expanded, Scopus) identifier identifier

  • Publication Type: Article / Article
  • Volume: 30
  • Publication Date: 2019
  • Doi Number: 10.1016/j.phytol.2019.02.006
  • Journal Name: PHYTOCHEMISTRY LETTERS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.261-272
  • Keywords: Piceatannol, Cholinesterases, Iris domestica, Irilin D, Resveratrol, ALZHEIMERS-DISEASE, C-13 NMR, MANGIFERIN, CONSTITUENTS, EXTRACTS, CHARGES
  • Lokman Hekim University Affiliated: No

Abstract

Isoflavonoids and stilbenes were suggested as potential lead structures for inhibition of cholinesterases and in management of dementia. The Traditional Chinese (TCM) herb Belamcandae chinensis rhizoma (the rhizome of Iris domestica (L.) Goldblatt & Mabb) contains both classes of natural products. Here, we isolated eight isoflavonoids: irisflorentin (1), tectorigenin(2), iristectorigenin B(3), irigenin (4), irilin D (5), iridin (6), tectoridin (7), iristectorin B (8), two stilbenes; piceatannol (9) and resveratrol (10) as well as the xanthone glucoside - mangiferin (11). The compounds weretested against acetyl-(AChE) and butyrylcholinesterase (BChE) using ELISA microtiter assay. Molecular docking studies were also performed on the active compounds.