Factor VII Deficiency in Pregnancy: A Case Series and Review of the Literature
Eastern Journal of Medicine, cilt.31, sa.3, ss.534-539, 2026 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 31 Sayı: 3
- Basım Tarihi: 2026
- Doi Numarası: 10.5505/ejm.2026.72246
- Dergi Adı: Eastern Journal of Medicine
- Derginin Tarandığı İndeksler: Scopus, EMBASE, TR DİZİN (ULAKBİM), Academic Search Ultimate (EBSCO), Biomedical Reference Collection: Corporate Edition (EBSCO), Health Research Premium Collection (ProQuest), Pharma Collection (ProQuest)
- Sayfa Sayıları: ss.534-539
- Anahtar Kelimeler: Factor VII deficiency, Postpartum haemorrhage, Pregnancy, Recombinant activated factor VIIa
- Lokman Hekim Üniversitesi Adresli: Evet
Özet
Factor VII (FVII) deficiency is the most common of the rare inherited coagulation disorders, but its behaviour during pregnancy is poorly characterised. We reviewed the peripartum course and delivery outcomes of pregnant women with FVII deficiency managed at a single tertiary centre. We retrospectively reviewed 10 consecutive pregnancies complicated by confirmed FVII deficiency and delivered between January 2010 and December 2023. Maternal characteristics, FVII activity, mode of delivery, peripartum management, and bleeding outcomes were recorded. Postpartum haemorrhage (PPH) was defined as blood loss exceeding 500 mL after vaginal delivery or 1000 mL after caesarean section. Mean maternal age was 30.6 ± 5.2 years and mean FVII activity closest to delivery was 19.6 ± 15.4%, with four women (40%) below 10%. Six women (60%) delivered by caesarean section. Prophylactic recombinant activated factor VII (rFVIIa) was given to nine women (90%), at a mean cumulative dose of 4.4 ± 2.3 mg. PPH occurred in five women (50%), four of whom had received prophylaxis. FVII activity did not predict bleeding: four of the five women with PPH had levels above 10%, whereas three of the four women with levels below 10% delivered without excess blee ding. FVII activity alone does not reliably predict bleeding risk during pregnancy, and PPH may occur despite prophylactic rFVIIa. Management should be individualised according to FVII activity, bleeding history, mode of delivery, and overall obstetric risk, with delivery planned at a tertiary centre with haematological support.