Molecular modeling and in vitro approaches towards cholinesterase inhibitory effect of some natural xanthohumol, naringenin, and acyl phloroglucinol derivatives


ERDOĞAN ORHAN İ., Jedrejek D., ŞENOL DENİZ F. S., Salmas R. E., DURDAĞI S., Kowalska I., ...Daha Fazla

PHYTOMEDICINE, cilt.42, ss.25-33, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 42
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1016/j.phymed.2018.03.009
  • Dergi Adı: PHYTOMEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.25-33
  • Anahtar Kelimeler: Xanthahumol, Naringenin, Acyl phloroglucinol, Cholinesterase, Molecular docking, HUMULUS-LUPULUS L., ALZHEIMERS-DISEASE, ACETYLCHOLINESTERASE INHIBITORS, PRENYLATED FLAVONOIDS, PROTEIN, ANTIOXIDANT, METABOLITES, EXTRACTS, DOCKING, SITE
  • Lokman Hekim Üniversitesi Adresli: Hayır

Özet

Background: Many natural products, particularly phenolic compounds, have been reported to have a strong inhibition against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), the key enzymes in the pathology of Alzheimer's disease (AD).