Molecular modeling and in vitro approaches towards cholinesterase inhibitory effect of some natural xanthohumol, naringenin, and acyl phloroglucinol derivatives

ERDOĞAN ORHAN, İLKAY; Jedrejek, Dariusz; ŞENOL DENİZ, FATMA; Salmas, Ramin; DURDAĞI, SERDAR; Kowalska, Iwona; Pecio, Lukasz; Oleszek, Wieslaw

doi:10.1016/j.phymed.2018.03.009

Molecular modeling and in vitro approaches towards cholinesterase inhibitory effect of some natural xanthohumol, naringenin, and acyl phloroglucinol derivatives

ERDOĞAN ORHAN İ., Jedrejek D., ŞENOL DENİZ F. S., Salmas R. E., DURDAĞI S., Kowalska I., ...More

PHYTOMEDICINE, vol.42, pp.25-33, 2018 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 42
Publication Date: 2018
Doi Number: 10.1016/j.phymed.2018.03.009
Journal Name: PHYTOMEDICINE
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.25-33
Keywords: Xanthahumol, Naringenin, Acyl phloroglucinol, Cholinesterase, Molecular docking, HUMULUS-LUPULUS L., ALZHEIMERS-DISEASE, ACETYLCHOLINESTERASE INHIBITORS, PRENYLATED FLAVONOIDS, PROTEIN, ANTIOXIDANT, METABOLITES, EXTRACTS, DOCKING, SITE
Lokman Hekim University Affiliated: No

Abstract

Background: Many natural products, particularly phenolic compounds, have been reported to have a strong inhibition against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), the key enzymes in the pathology of Alzheimer's disease (AD).