Akademik Veri Yönetim Sistemi
Turkiye Klinikleri Journal of Medical Sciences, cilt.28, sa.5, ss.640-647, 2008 (SCI-Expanded)
Objective: Although regimens of harvesting peripheric stem cell vary from one center to another, the most common ones are growth factor plus chemotherapy or growth factor alone. In our study, we aimed to determine which regimens of harvesting peripheral stem cell are more effective on the number of CD34(+) cells. Material and Methods: Between March 2004 and June 2007, sixty six cases included in the autologous peripheral stem cell harvesting program in the Ankara Numune Hospital Bone Marrow Transplantation Unit were evaluated retrospectively. They were diagnosed with Hodgkin's disease, non Hodgkin lymphoma, multiple myeloma, and testis germ cell tumor. Regarding harvesting regimes, 41 cases were administered cyclophosphamid + etoposide + filgrastim 5 μg/kg/day (CEF), 7 cases cyclophosphamid + filgrastim 5 μg/kg./day (CF), and 18 cases filgrastim 10 μg/kg/day (F). Results: In the CEF, CF, and F groups, the median duration of filgrastim treatment before harvesting CD34(+) cells was 9, 10 and 5 days respectively. The difference was statistically significant between CEF-F and CF-F groups in terms of the duration of filgrastim treatment before harvesting CD34(+) cells (p< 0.01). The median number of CD34(+) cell apheresis was 1, 2, 2 in the CEF, CF, and F groups, respectively. The difference between the CEF and F groups (p> 0.001) regarding the number of apheresis was allso significant. In the CEF, CF, and F groups, the median number of harvested CD34(+) cells were 7.36 × 106/kg, 3.4 × 106/kg, and 4.1 × 106/kg respectively; the difference between the CEF-CF and CEF-F groups was statistically significant (p= 0.004 and p< 0.001). Conclusion: Higher number of CD34(+) cells can be harvested with the CEF regimen compared to the CF and F regimens. Filgrastim 10 μg/kg/day could harvest an adequate number of CD34(+) cells despite the requirement for more apheresis procedures. The effect of harvesting regimens on engrafment will be evaluated later in our center. Copyright © 2008 by Türkiye Klinikleri.