Akademik Veri Yönetim Sistemi
Journal of Clinical and Analytical Medicine, cilt.6, sa.1, ss.79-82, 2015 (ESCI)
© 2015 Journal of Clinical and Analytical Medicine. All Rights Reserved.Aim: Until now many researches have showed that Helicobacter pylori in-fection may be etiological factor of colorectal cancer. The aim of current study was to investigate the frequency of H.pylori infection seropositivity of colorectal cancer patients and compare the clinicopathological features of H.pylori positive patients with negative ones. Material and Method: Seventy four colorectal patients were included in study. Retrospectively, patients clini-cal features, surgery history and pathological characteristics were screened. Patients group serum samples were collected. H.pylori Ig G level were quan-titatively measured with ELISA method and levels above 5 arbU/ml were ac-cepted as seropositive. Results: Patients median age was 60.5 (range 26-83) and 56.8% (n=42) were male. H.pylori Ig G was positive in 37.8% (n=28) and negative in 62.2% (n=46) of patient group. H.pylori serpositive and nega-tive patients median age of diagnosis were 56 and 64 respectively (p=0.01). There were no significant difference between H.pylori seropositive group when compared with negative group according to age, level of CEA and Ca 19-9, stage, lymph node involvement, perineural and vascular invasion, presence of polyps, differantion, localisation of tumours. Discussion: H.pylori seropositive patients were diagnosed at younger age. Association of this finding with etiology was confusing. Further studies with healthy controls may provide detailed information about whether H.pylori seropositivity is as-sociated with colorectal cancer etiology.