The plasma levels of prostanoids and plasminogen activator inhibitor-1 in primary and secondary thrombocytosis


BİRDANE A., HAZNEDAROĞLU İ. C., Bavbek N., KOŞAR A., BÜYÜKAŞIK Y., ÖZCEBE O. İ., ...More

Clinical and Applied Thrombosis/Hemostasis, vol.11, no.2, pp.197-201, 2005 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 11 Issue: 2
  • Publication Date: 2005
  • Doi Number: 10.1177/107602960501100209
  • Journal Name: Clinical and Applied Thrombosis/Hemostasis
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.197-201
  • Keywords: thrombocytosis, plasminogen activator inhibitor type 1, thromboxane A2, 6-keto-PGF1 alpha, INCREASED THROMBOXANE BIOSYNTHESIS, ARACHIDONIC-ACID METABOLISM, MYELOPROLIFERATIVE DISORDERS, PLATELET ACTIVATION, WHOLE-BLOOD, T-PA, PAI-1, PROSTACYCLIN, TRANSPLANTATION, FIBRINOLYSIS
  • Lokman Hekim University Affiliated: No

Abstract

An elevated platelet count is a common finding in both hospitalized and ambulatory patients. Thrombosis and bleeding complications are more frequently observed in patients with clonal thrombocytosis than secondary thrombocytosis. The aim of this study was to investigate the behaviors of plasminogen activator inhibitor type 1 (PAI-1), the inhibitor of fibrinolysis; and thromboxane A2 and 6-keto-PGF1 α, the products of endoperoxides, in 16 patients affected with clonal thrombocytemia as compared with 16 patients with reactive thrombocytosis and 15 normal controls. In the clonal thrombocytemia group, plasma levels of PAI-1 antigen and activity were significantly higher than both reactive thrombocytosis and control group. Plasma levels of 6-keto-PGF1α were significantly higher in the clonal thrombocytemia group than the other two groups and also higher in the reactive thrombocytosis group than the control group, which was also significant. This study confirms that arachidonate metabolism is frequently deranged in patients with thrombocytosis and hypofibrinolysis due to increased PAI-1 plasma levels as shown in the clonal thrombocytosis group. This may explain the thrombotic tendency in myeloproliferative disorders. © 2005 Westminster Publications, Inc.