Enzyme inhibitory and antioxidant potential with phytochemical analysis of Satureja hasturkii H.Duman & Dirmenci: A new record from Türkiye

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Büyükyıldırım T., Öcal Özdamar F., Baysal Furtana G., Gök H. N., Özek T., Şenol Deniz F. S., ...More

CHEMISTRY AND BIODIVERSITY, vol.22, no.-, pp.1-10, 2025 (SCI-Expanded, Scopus)

  • Publication Type: Article / Article
  • Volume: 22 Issue: -
  • Publication Date: 2025
  • Doi Number: 10.1002/cbdv.202500328
  • Journal Name: CHEMISTRY AND BIODIVERSITY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Agricultural & Environmental Science Database, Aquatic Science & Fisheries Abstracts (ASFA), CAB Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.1-10
  • Lokman Hekim University Affiliated: Yes

Abstract

The genus Satureja (Lamiaceae) includes many aromatic species with known antimicrobial, antioxidant, anti-inflammatory,

and anticancer properties. Satureja hasturkii H.Duman & Dirmenci is a newly described species from Türkiye (2023), and its

biologicalpotentialhasnotbeenexploredyet.Inthisstudy,dichloromethane(DCM),ethylacetate(EtOAc),andethanol(EtOH)

extracts were assessed for their enzyme inhibitory activity against acetylcholinesterase (AChE), butyrylcholinesterase (BChE),

elastase,collagenase,tyrosinase(TYR),andxanthineoxidase(XO),alongwiththeirantioxidantactivitiesusingDPPH,nitricoxide

(NO), metal-chelation,ferric-reducingantioxidantpower (FRAP),and cupric-reducingantioxidantcapacity (CUPRAC) assays.

The extracts showed low to moderate inhibition levels at 2 mg/mL (stock concentration). The EtOAc extract showed the most

effectiveelastase(16.70± 2.08%)andcollagenase(13.96± 3.70%)inhibition.XOinhibitionwashighestwithEtOH(34.34± 0.60%),

followedbyEtOAcextract(30.32± 2.03%).DCMextractdisplayedthestrongestmetal-chelatingactivity(72.38± 1.86%).Essential

oilcompositionanalyzedbyGC-MSrevealeddocosane,γ-terpinene,andp-cymeneasmajorconstituents.HPLCanalysisofthe

extractsidentifiedrosmarinicacidandluteolin-7-O-glucosideasabundantphenolics.Theseresultshighlightthespecies’potential

asanaturalsourceofbioactiveagentsforpharmaceuticalandnutraceuticalapplications.