Neopterin: A promising marker for the inflammation in polycystic ovary syndrome


ALANBAY İ., Mutlu Ercan C., Coksuer H., Sakinci M., Karasahin K. E. , Ozturk O., ...More

Gynecological Endocrinology, vol.28, no.11, pp.879-883, 2012 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 28 Issue: 11
  • Publication Date: 2012
  • Doi Number: 10.3109/09513590.2012.683072
  • Journal Name: Gynecological Endocrinology
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.879-883
  • Keywords: PCOS, neopterin, inflammation, macrophages, LOW-GRADE INFLAMMATION, IMMUNE-SYSTEM ACTIVATION, INSULIN-RESISTANCE, ADIPOSE-TISSUE, OXIDATIVE STRESS, DIAGNOSTIC-CRITERIA, FAT DISTRIBUTION, ADIPOCYTE DEATH, OBESE WOMEN, MACROPHAGES

Abstract

Background: Several markers of low-grade chronic inflammation are altered in women with polycystic ovary syndrome (PCOS). Neopterin (NEO) is a marker of celullar immunity, and oxidative stress, mainly produced by activated macrophages. We aimed to evaluate the NEO levels in PCOS patients and correlate them with antropometric and biochemical parameters. Methods: The study groups consisted of 69 women with PCOS and 46 healthy controls. Both groups were divided into two subgroups according to their body mass index (BMI): <25 = normoweight, >25 = overweight. The clinical and biochemical parameters and serum NEO levels were analyzed. Results: Circulating levels of NEO were significantly (p < 0.001) higher in women with PCOS (normoweight: 15.9 ± 4.7 nmol/l; overweight 13.3 ± 8.1 nmol/l) compared to controls (normoweight: 8.6 ± 2.0 nmol/l; overweight 9.2 ± 1.8 nmol/l) regardless of their weight classes. Waist-to-hip ratio (WHR) (p < 0.05), free and total testosterone (p < 0.001) were significantly elevated in women with PCOS compared to controls after controlling for the effect of obesity. Conclusion: Circulating NEO level s are elevated in PCOS independent of body mass index supporting the suggestion of PCOS is a low-grade chronic inflammatory state. © 2012 Informa UK, Ltd.