Akademik Veri Yönetim Sistemi
Anestezi Dergisi, cilt.20, sa.3, ss.147-153, 2012 (Scopus)
Objective: Nausea and vomiting are common and unpleasant side effects of children undergoing general anesthesia. We investigated the antiemetic effects of ondansetron and midazolam by accounting the incidence of nausea and vomiting after tonsillectomy and adenoidectomy. Method: A randomized, double-blind trial was performed. Sixty children, 1,5-14 years of age who were undergoing tonsillectomy and adenoidectomy were included in this study. After the premedication with midazolam, patients were divided as midazolam group (GM), ondansetron group (GO) and control group (GC)s. Anaesthesia was induced with sevoflurane, thiopental, vecuronium and fentanyl. After the intubation; patients received 75 μg kg -1 midazolam in GM, 150 μg kg -1 ondansetron in GO and 5 ml SF solution in GC. Anaesthesia was maintaned by N 2O, sevoflurane and O 2. After the operation, fentanyl (0,5 μg kg -1) was administered in post-anaesthetic recovery room (PAR) and acetominophen (10 μg kg -1, po/im) was given in the Day Care Surgical Unit (DCSU), if the CHEOPS (Children's Hospital of Eastern Ontorio Pain Scale) pain score was more than 6. Patients who have 3 score of PONV in PAR or DCSU was administered metocloropamid (150 μg kg -1, i.v.). Patients were evaluated who arrived in DCSU after 45 min and 24th hours for the incidence of nausea, vomiting and quality of oral intake(QOI). Results: The groups were similar with respect to demographic data, additional drugs reqruitment, duration of stay in the PAR and DCSU and PONV score in these units. There were no diffences between the GM and GO in 24 th hrs of PONV scores (p>0.05). OQI scores at the 24 th hrs were different for all groups especially in the OG (p<0.05). Conclusion: Being more pronounced with ondansetron; ondansetron and midazolam were found to increase the QOI by decreasing PONV score at the 24 th hours.