The ameliorating effects of Vitamin E on hepatic antioxidant system and xenobiotic-metabolizing enzymes in fenvalerate-exposed iodine-deficient rats
Drug and Chemical Toxicology, vol.39, no.3, pp.264-271, 2016 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 39 Issue: 3
- Publication Date: 2016
- Doi Number: 10.3109/01480545.2015.1092041
- Journal Name: Drug and Chemical Toxicology
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.264-271
- Keywords: Cytochrome P450, xenobiotic-metabolizing enzymes, thyroid hormones, iodine deficiency, fenvalerate, Vitamin E, INDUCED OXIDATIVE STRESS, CYTOCHROME-C REDUCTASE, PYRETHROID INSECTICIDES, GLUTATHIONE-PEROXIDASE, CARDIOVASCULAR-DISEASE, ALPHA-TOCOPHEROL, INDUCTION, LIVER, BRAIN, ACID
- Lokman Hekim University Affiliated: No
Abstract
© 2016 Taylor & Francis.This study investigated the effects of Vitamin E (VE) on hepatic antioxidant system and drug-metabolizing enzymes in fenvalerate (FEN)-exposed iodine-deficient (ID) Wistar rats. ID was produced by perchlorate containing drinking water. VE was introduced by a loading dose of 100 mg/kg/d, i.g. for the first three days in the last week of feeding period; then with a single maintenance dose of 40 mg/kg on the 4th day. During last week, FEN groups (F) received 100 mg/kg/d, i.p. FEN. VE alone did not significantly affect thyroid hormones and antioxidant parameters; however, significantly increased total cytochrome P450 (38%) and cytochrome b5 levels (36%). In all ID groups, plasma thyroid-stimulating hormone (TSH) levels increased markedly, but remained at control level in Vitamin E plus FEN receiving iodine-deficient group (IDVF) group. Glutathione peroxidase activity showed marked increases in F (19%) and FEN-exposed iodine-deficient group (IDF, 48%) groups. FEN treatment significantly increased total cytochrome P450 (28%) and thiobarbituric acid reactive substance levels (36%), as well as 7-ethoxyresorufin O-deethylase (120%), 7-penthoxyresorufin O-deethylase (139%) and glutathione S-transferase (15%) activities and decreased total glutathione concentrations (28%) versus control. Overall results suggest that Vitamin E has ameliorating effects on the measured parameters in ID and/or FEN exposure.