Flavonoids with antinociceptive and anti-inflammatory activities from the leaves of Tilia argentea (silver linden)
Journal of Ethnopharmacology, cilt.95, sa.2-3, ss.393-397, 2004 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 95 Sayı: 2-3
- Basım Tarihi: 2004
- Doi Numarası: 10.1016/j.jep.2004.08.008
- Dergi Adı: Journal of Ethnopharmacology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.393-397
- Anahtar Kelimeler: Anti-inflammatory, Antinociceptive, Flavonoids, Tilia argentea
- Lokman Hekim Üniversitesi Adresli: Hayır
Özet
Silver linden, Tilia argentea Desf. ex DC (Tiliaceae) leaves are used in the treatment of common cold and bronchitis. In order to evaluate this information, antinociceptive and anti-inflammatory activities of the two main flavonoid glycosides: kaempferol-3,7-O-α-dirhamnoside and quercetin-3,7-O-α-dirhamnoside isolated from the leaves, were investigated. For the antinociceptive activity, p-benzoquinone-induced writhing test and for the anti-inflammatory activity, carrageenan-induced hind paw edema model in mice were used. Both compounds were shown to possess potent antinociceptive and anti-inflammatory activity at 50 mg/kg dose, per os, without inducing any apparent acute toxicity as well as gastric damage. © 2004 Elsevier Ireland Ltd. All rights reserved.