Metrics
Publication
24
Open Access
3
UN Sustainable Development Goals
Biography
Dr. Ofcan Oflaz is a faculty member at Lokman Hekim University's Faculty of Medicine, specializing in Medical Biology and Genetics. His research spans molecular biology, virology, and medical genetics, with a focus on bioinformatics and protein engineering. Through his work, Dr. Oflaz has advanced knowledge in hereditary genetics and the application of computational tools in biological modeling. He has contributed to numerous publications, which are widely cited for their impact on molecular diagnostics and targeted therapies. His expertise includes homology modeling, protein interactions, rare disease and the application of bioinformatics in personalized medicine, significantly shaping research in infectious diseases and medical diagnostics.
Education
2017 - 2023
2017 - 2023Doctorate
Hacettepe University, Fen Bilimleri Enstitüsü, Biyoloji A.B.D., Turkey
2014 - 2017
2014 - 2017Postgraduate
Hacettepe University, Fen Bilimleri Enstitüsü, Moleküler Biyoloji (Yl) (Tezli), Turkey
2010 - 2014
2010 - 2014Undergraduate
Hacettepe University, Fen Fakültesi, Biyoloji Bölümü, Turkey
Dissertations
2023
2023Doctorate
Researching of Resistance To Etravirine In Some HIV-1 Low-Level Viremia Straıns By In-Silico And In-Vitro Methods
Hacettepe University, Fen Bilimleri Enstitüsü, Biyoloji A.B.D.
2017
2017Postgraduate
AVPR2 proteininin homoloji temelli üç boyutlu yapı modellemesi
Hacettepe University, Fen Bilimleri Enstitüsü, Biyoloji A.B.D.
Research Areas
Medical Biology
Medical Genetics
Structural Biology
Bioinformatics
Biological Modelling
Biological Databases
Genetic Disorders
Protein Engineering
Research Areas Based on Academic Activities
Avesis Research Areas
WoS Research Areas
Scopus Research Areas
Academic Positions
2020 - Continues
2020 - ContinuesLecturer
Lokman Hekim University, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü
Managerial Experience
2022 - Continues
2022 - ContinuesYAZILIM İŞLERİ KOMİSYON ÜYESİ
Lokman Hekim University, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü
2022 - Continues
2022 - ContinuesMEZUNİYET ÖNCESİ EĞİTİM SEMİNERLERİ KOORDİNATÖRÜ
Lokman Hekim University, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü
2022 - Continues
2022 - ContinuesSimülasyon Merkezi Kurulu Üyesi
Lokman Hekim University, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü
2022 - Continues
2022 - ContinuesTıp Fakültesi Seçmeli Dersler Kurulu Üyesi
Lokman Hekim University, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü
2022 - Continues
2022 - ContinuesÖlçme Değerlendirme Kurulu Üyesi
Lokman Hekim University, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü
2022 - Continues
2022 - ContinuesTIP FAKÜLTESİ İNTERNET SİTESİ SORUMLUSU
Lokman Hekim University, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü
2021 - Continues
2021 - ContinuesUygulama ve Araştırma Merkezi Yönetim Kurulu Üyesi
Lokman Hekim University, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü
2021 - 2023
2021 - 2023Phase Assistant Coordinator
Lokman Hekim University, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü
2020 - 2022
2020 - 2022Project Specialist of Scientific Research Projects Coordinatorship
Lokman Hekim University, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü
Non Academic Experience
2018 - 2020
2018 - 2020Product manager
Business Establishment Private, LABTEK, Moleküler Ürünler departmanı, Product manager
Courses
Undergraduate
Undergraduate
Virüslerle Savaş
Medical Biology and Genetics
Genetic Diseases and Counseling
Etkili Sunum Teknikleri
Social Media and Popular Science
Genden Proteine Moleküler Yolculuk
Akademik Poster ve Sözlü Sunum Hazırlama
Eczacılıkta In-silico Yaklaşım
Social Media Use in Health
Molecular Clue of Diagnosis
Taught Courses and Trainings
2021 - 2021
2021 - 2021Uygulamalı Biyoinformatik Eğitimi II
Application Research Center - Certificate Program
Türk C., Oflaz O., Yaylacı S.
2020 - 2020
2020 - 2020Uygulamalı Biyoinformatik Kursu I
Continuing Education Center - Course
Güçlü Durgun S., Oflaz O.
Articles
All (12)
SCI-E, SSCI, AHCI (8)
SCI-E, SSCI, AHCI, ESCI (9)
ESCI (1)
Scopus (8)
TRDizin (1)
Other Publications (2)
2025
20251. Homozygous PGAP2 Mutation Causes Hyperphosphatasia with Mental Retardation Syndrome-3: Genetic and Clinical Evaluation of the Ultra-Rare Inherited Glycosylphosphatidylinositol Biosynthesis Defect
Yavaş A. K., Özbey S. Z., Ergin B., Ünal Y., Bilginer Gürbüz B., Karaatmaca B., et al.
Molecular Syndromology
, vol.16, no.5, pp.476-488, 2025 (SCI-Expanded, Scopus)
2025
20252. Mechanistic Insights into Systemic Targets of Magnolia Mediating Beneficial Effects in Metabolic Syndrome through Biochemical and In Situ Analyses
OFLAZ O., TURAN B.
Biochemical Genetics
, 2025 (SCI-Expanded, Scopus)
2025
20253. A novel case with CHST14-related musculocontractural Ehlers-Danlos syndrome
Ardicli D., Degerliyurt A., Genc B. F., OFLAZ O., CEYLANER S.
Neurology Asia
, vol.30, no.3, pp.943-946, 2025 (SCI-Expanded, Scopus)
2024
20244. Allomaltol derivatives as Antimycobacterial agents: In vitro and in silico evaluations with potential protein targets
Oflaz O.
JOURNAL OF PHARMACY OF ISTANBUL UNIVERSITY , vol.54, no.3, pp.446-455, 2024 (TRDizin)
2023
20235. Bioinformatics analysis of wild-type ParC and S79F, S79Y mutations in Streptococcus pneumoniae
Akgün Karapınar D. B., Oflaz O.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
, vol.27, no.15, pp.6931-6938, 2023 (SCI-Expanded, Scopus)
2023
20236. Researching of resistance to etravirine in some HIV-1 low-level viremia strains by in-silico methods
Oflaz O., Mergen H., Demir T.
TURKISH JOURNAL OF BIOCHEMISTRY , vol.1, no.1, pp.1-6, 2023 (SCI-Expanded, Scopus)
2023
20237. Exercise and COVID-19: exercise intensity reassures immunological benefits of post-COVID-19 condition.
Thirupathi A., Yong W., Oflaz O., Agascioglu E., Gu Y.
Frontiers in physiology
, vol.14, pp.1036925, 2023 (SCI-Expanded, Scopus)
2023
20238. Toxic effects of Aroclor 1254 on rat liver and modifying roles of selenium
Balcı Özyurt A., ERKEKOĞLU Ü. P., ZEYBEK N. D., Aşcı A., Yaman Ü., OFLAZ O., et al.
International Journal of Environmental Health Research
, vol.33, no.12, pp.1289-1304, 2023 (SCI-Expanded, Scopus)
2021
20219. The Relationship of the HFE Gene H63A Mutant Type with Aerobic Exercise and A Bioinformatics Analysis
Oflaz O., Ağaşcıoğlu E. A.
Journal of Athletic Performance and Nutrition
, vol.8, no.1, pp.15-23, 2021 (Peer-Reviewed Journal)
2021
202110. The Effect of Aerobic Exercise on Deteriorating VO2max and Diminished Mitochondrial Biogenesis During Aging
AĞAŞCIOĞLU E. A., OFLAZ O.
PAKISTAN JOURNAL OF MEDICAL & HEALTH SCIENCES
, vol.15, no.12, pp.3462-3466, 2021 (ESCI)
2021
202111. The Importance of ACTN3 R577X Polymorphism in Athletic Performance and Modeling of R577X Mutant Type and Wild Type ACTN3 Protein by Bioinformatics Analysis
Oflaz O., Altıntaş N.
Cumhuriyet Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi / Journal of Cumhuriyet University Health Sciences Institute
, vol.6, no.1, pp.17-22, 2021 (Peer-Reviewed Journal)
2020
202012. Renal changes and apoptosis caused by subacute exposure to Aroclor 1254 in selenium-deficient and selenium-supplemented rats
ZEYBEK N. D., SUR Ü., Oflaz O., ERKEKOĞLU Ü. P., Balci A., ÖZKEMAHLI K. G., et al.
Arhiv za Higijenu Rada i Toksikologiju
, vol.71, no.2, pp.110-120, 2020 (SCI-Expanded, Scopus)
Papers Presented at Peer-Reviewed Scientific Conferences
2023
20231. Investigation of Synthesis and The Biological Effect Profiles of New Benzimidazole Derivative
ŞEN H. T., OFLAZ O., KILCIGİL G.
9th International BAU Drug Design Congress, İstanbul, Turkey, 29 November - 02 December 2023, (Summary Text)
2022
20222. ANALYZING OF EFAVIRENZ RESISTANCE OF SOME REVERSE TRANSCRIPTASE MUTATIONS BY IN-SILICO METHOD
Oflaz O., Şen H. T.
8th International BAU Drug Design Congress, İstanbul, Turkey, 15 - 17 December 2022, (Unpublished)
2022
20223. Creation of Homology Models of Some HIV-1 Integrase Mutations and Investigation of Their Relationship with Cabotegravir by In Silico Methods
Şen H. T., Oflaz O., Çelik İ.
8th International BAU Drug Design Congress, İstanbul, Turkey, 15 - 17 December 2022, pp.1, (Summary Text)
2022
20224. MARİBAVİR DİRENCİNE YOL AÇAN H411Y MUTASYONUNUN IN-SILICO ANALİZİ
Şen H. T., Oflaz O.
III. Lokman Hekim Eczacılık Günleri Pharmacopolium ile 21. Yüzyılda Eczacılık, Ankara, Turkey, 10 - 12 May 2022, pp.20, (Full Text)
2021
20215. The Cellular Response of The Oxygen Sensitive Soleus Muscle to Acute and Chronic Hypoxia via HIF1α, HSP90, and nNOS
Oflaz O., Ağaşcıoğlu E. A.
VIII. International Congress Of Molecular Medicine, İstanbul, Turkey, 9 - 12 November 2021, (Unpublished)
2021
20216. Amprenavir’in Covid-19 ve HIV Hedef Bölgelerinin Karşılaştırmalı Biyoinformatik Analizi
Oflaz O.
3. Ulusal Viroloji Günleri, İstanbul, Turkey, 19 - 20 June 2021, pp.137, (Full Text)
2020
20207. Mycobacterium tuberclosis Yabanıl Tip ve Bazı Mutant rpoB Enzimlerinin Biyoinformatik Analizleri.
Oflaz O., Erikçi A.
Türk Mikrobiyoloji Cemiyeti Çevrim İçi Mikrobiyoloji Sempozyumu, İstanbul, Turkey, 25 December 2020, (Summary Text)
2020
20208. Mycobacterium tuberclosis Ser531Leu Mutant ve Yabanıl Tip rpoB Enzimlerinin Biyoinformatik Analizleri.
OFLAZ O., Altuntaş S., ERİKÇİ A.
9. Ulusal Moleküler Biyoloji ve Biyoteknoloji Kongresi, Turkey, 19 December 2020, (Summary Text)
2015
20159. Protective role of dietary selenium on toxic effects of Aroclor 1254 in brain tissues of rats
Oflaz O., Sur Ü., Gümüşel B., Zeybek N. D., Balcı Özyurt A., Erkekoğlu Ü. P.
9th Congress of the Turkish Society of Toxicology with the participation of the Hellenic Society of Toxicology, İzmir, Turkey, 21 - 24 October 2015, pp.44, (Summary Text)
Books
2023
20231. Mechanism of HIV-1 Reverse Transcriptase Inhibitors
Oflaz O.
in: Current Researches in Health Sciences-IV, Canan Demir,İsmet Meydan, Editor, Özgür Yayın-Dağıtım, Gaziantep, pp.1-13, 2023
2021
20212. HOMOLOGY MODELLİNG
Oflaz O.
in: TEMEL TIP BİLİMLERİNDE GÜNCEL YAKLAŞIMLAR, Doç. Dr. Nihayet Bayraktar,Prof. Dr. Mehmet Bayraktar, Editor, İksad Yayınevi, Ankara, pp.203-219, 2021
2021
20213. NUTRİTİONAL GENOMİCS
Oflaz O., Tengiz T.
in: TEMEL TIP BİLİMLERİNDE GÜNCEL YAKLAŞIMLAR, Doç. Dr. Nihayet Bayraktar,Prof. Dr. Mehmet Bayraktar, Editor, İksad Yayınevi, Ankara, pp.175-202, 2021
Funded Projects
2022 - 2024
2022 - 2024An investigation on protective role of a natural supplement including magnolol and honokiol on the insufficient heart function by using electrophysiological and biochemical-molecular techniques
Project Supported by Higher Education Institutions , BAP Research Project
Oflaz O., Turan B. (Executive)
2021 - 2024
2021 - 2024İnsülin direnci gibi toplumları yakından ilgilendiren sendromların altında yatan mekanizmaların incelenmesinde temel tıp araştırmaları ve uygulamaları: Preklinik araştırmaların yapılandırılmasında elektrofizyolojik, histolojik, biyokimyasal ve moleküler tekniklerin kullanılması
Project Supported by Higher Education Institutions , BAP Infrastructure
Atıcı Y., Özgüven Ş. V. (Executive), Yıldırımkaya M. M., Oflaz O., Göktaş G., Üner S., et al.
2020 - 2021
2020 - 2021Mycobacterium tuberclosis Mutant ve Yabanıl Tip rpoB Enzimlerinin Biyoinformatik Analizleri
Project Supported by Higher Education Institutions , BAP Research Project
Erikçi A. (Executive), Oflaz O.
Roles in Event Organizations
Ocak 2023
Ocak 2023İletişim ve Yaklaşım Becerileri Çalıştayı
Workshop Organization
Öz F., Dursun A. B., Belen H. M., Oflaz O.
Ankara, Turkey