Profiling the annual change of the neurobiological and antioxidant effects of five Origanum species in correlation with their phytochemical composition

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GÖK H. N., Luca S. V., Ay S. T., Komsta L., Salmas R. E., ERDOĞAN ORHAN İ., ...More

FOOD CHEMISTRY, vol.368, 2022 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 368
  • Publication Date: 2022
  • Doi Number: 10.1016/j.foodchem.2021.130775
  • Journal Name: FOOD CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, Aerospace Database, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, CAB Abstracts, Chemical Abstracts Core, Chimica, Communication Abstracts, Compendex, EMBASE, Food Science & Technology Abstracts, MEDLINE, Metadex, Veterinary Science Database, Civil Engineering Abstracts
  • Keywords: Origanum, Oregano, Cholinesterase, Antioxidant, HPLC-DAD-ESI, HRMS, Correlation, LIQUID-CHROMATOGRAPHY, TRADITIONAL MEDICINE, FOLK MEDICINE, ORIGANUM, ACETYLCHOLINESTERASE, FLAVONOIDS, EXTRACTS, DISEASE, PROTEIN, TURKEY
  • Lokman Hekim University Affiliated: No

Abstract

The ethanol extracts of five Origanum species: O. majorana L., O. onites L., O. syriacum L., O. vulgare subsp. hirtum (Link) Ietsw., and O. vulgare subsp. viride (Boiss.) Hayek, collected annually (each month), were investigated for their cholinesterase inhibition and antioxidant effects. The phytochemical composition of a total of 60 extracts was assessed by HPLC-DAD-ESI/HRMS, revealing the presence of a total of 73 compounds. Possible correlation between the bioactivity and metabolite profiles during 12 months was monitored. Acetylcholinesterase (AChE) inhibitory activity was found to be the highest between April and November (50.29-75.95%, 200 mu g/mL), while the highest inhibition towards butyrylcholinesterase (BChE) was observed for the extracts between April and October (71.68-88.97%). Aromadendrin showed good correlation with anti-AChE, anti-BChE and reducing power activities. Furthermore, molecular docking data with aromadendrin, caffeoylarbutin and eriodictyol indicated that caffeoylarbutin had the lowest binding energy against both enzymes.