Prenatal exposure to artificial food colorings alters NMDA receptor subunit concentrations in rat hippocampus

Doguc D. K., Deniz F., İLHAN İ., ERGÖNÜL E., Gultekin F.

Nutritional Neuroscience, cilt.24, sa.10, ss.784-794, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 24 Sayı: 10
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1080/1028415x.2019.1681065
  • Dergi Adı: Nutritional Neuroscience
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, CINAHL, EMBASE, Food Science & Technology Abstracts, MEDLINE, SportDiscus, Veterinary Science Database
  • Sayfa Sayıları: ss.784-794
  • Anahtar Kelimeler: Artificial food colors, spatial learning and memory, NR2A, NR2B, alpha 7 nAChR, open field test, forced swim test, NMDARs, NICOTINIC ACETYLCHOLINE-RECEPTORS, ADDITIVE EFSA PANEL, NEUROBEHAVIORAL TOXICITY, SCIENTIFIC OPINION, NUTRIENT SOURCES, DOUBLE-BLIND, FORCED-SWIM, MICE, MEMORY, REEVALUATION
  • Lokman Hekim Üniversitesi Adresli: Hayır

Özet

© 2019 Informa UK Limited, trading as Taylor & Francis Group.Exposure to artificial food color additives (AFCAs) has been implicated in the etiology of certain childhood hyperactivity and learning disabilities. N-methyl-D-aspartate receptors and alpha-7 nicotinic acetylcholine receptor (α7 nAChR) are involved in learning and memory. We administered a mixture of AFCAs (erythrosine, ponceau 4R, allura red AC, sunset yellow FCF, tartrazine, amaranth, brilliant blue, azorubine, and indigotine) to female rats during gestation to investigate the effects of prenatal exposure to AFCAs on neurobehavior, spatial learning, and memory in their offspring. We also investigated whether AFCAs modulate NR2A, NR2B, and α7 nAChR protein levels in their offsprings’ hippocampi. Although spatial learning and memory were not altered, the offspring of rats exposed to AFCAs exhibited decreased motivation and increased despair-related behavior. NR2A and NR2B protein levels were significantly reduced in female offspring in the experimental group (p < 0.05), whereas α7 nAChR level was not significantly altered. Our results suggest that prenatal exposure to AFCAs may lead to sex-dependent alterations in glutamatergic signaling which may continue into adolescence.