The Effect of Nitrogen Mustard on the Enzymatic Antioxidant Defense of Rat Brain Tissue and the Therapeutic Value of Proanthocyanidin


Tekiner A., Yucel D., Bayar M. A., Yucel O., Erdem Y., Karakaya J.

TURKISH NEUROSURGERY, vol.21, no.4, pp.461-466, 2011 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 4
  • Publication Date: 2011
  • Doi Number: 10.5137/1019-5149.jtn.4028-10.3
  • Journal Name: TURKISH NEUROSURGERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.461-466
  • Keywords: Nitrogen mustard, Antioxidants, Proanthocyanidin, Rat brain, CHEMICAL WARFARE, SULFUR MUSTARD, ALKYLATING ANTICANCER, NITRIC-OXIDE, MECHLORETHAMINE, TOXICITY, PEROXYNITRITE, PROTECTION, DRDE-07, DISEASE
  • Lokman Hekim University Affiliated: No

Abstract

AIM: Nitrogen Mustard (NM) is an alkylating agent that damages cellular nuclear DNA after penetrating tissue. This results in cytostatic, mutagenic and cytotoxic effects. We used biochemical analyses to investigate the effect of NM gas administered through the dermal and respiratory routes, on the brain cortex of rats and also tried to show whether the antioxidant Proanthocyanidin (PC) could decrease this effect.